A negative result means that the laboratory did not find a variant in the genes tested.Â
A negative result in people with symptoms of FTD:
- The majority of people with an FTD diagnosis but no family history of FTD do not have an identifiable genetic variant.
- Not everyone with a family history has an identifiable genetic variant.
- The lab only reports on the genes included in the test order. If the test did not include all genes associated with FTD, additional testing may be needed.
- Genetic testing today is limited to the genes related to FTD that have been discovered.
Over time, scientists will likely identify additional genes that cause FTD. People with FTD who test negative should consider DNA banking to allow for additional genetic testing in the future, when new genes are identified or there are advances in our understanding of the genetics of FTD.
A negative result in people without symptoms of FTD:
True Negative
If the genetic variant in the family is known, a negative result is a true negative. The lab specifically looked for the familial variant but did not find it. Therefore, the person tested did not inherit the variant; their risk of developing FTD is the same as the general population.
The children of someone with a true negative result are not at risk of inheriting the familial variant and do not need genetic testing for FTD.
Uninformative Negative
If the genetic variant in the family is unknown, a negative genetic test result in a person without symptoms is considered an uninformative negative.
It is possible their relative's FTD could be caused by a gene that has yet to be identified. To help avoid an uninformative negative, a symptomatic person should be the first person tested in a family, whenever possible.