Today’s research leads to tomorrow’s breakthroughs.
Grants Portfolio - Active Awards
AFTD-ADDF Accelerating Drug Discovery for FTD
Novel prolyl oligopeptidase ligands to target Tau in frontotemporal dementia and other tauopathies
Timo Myöhänen, PhD | Polku Therapeutics
2024
$282,600
Mitigating TDP-43 loss of function and disease initiation in FTD thru repair of the Nuclear Pore and CHMP7/ESCRT3 dysfunction
Jeffrey Rothstein, MD, PhD | Johns Hopkins School of Medicine
2023
$269,967
Selecting lead candidate REV-ERB agonist for the treatment of FTD
Robert Williams, PhD | Pelagos Pharmaceuticals
2022
$214,118
Discovery of selective LRP1 inhibitors to prevent tau uptake and spread
Kenneth Kosik, MD | University of California Santa Barbara
2020
$300,000
Development of PIKFYVE antisense oligonucleotides (ASO) treatment for FTD
Wen-Hsuan Chang, PhD | AcuraStem Inc.
2020
$165,000
Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease
Edward Huey, MD | Columbia University Medical Center
2015
$263,830
AFTD-ADDF Diagnostics Accelerator
Neurofilament (Nf) as a Fluid Biomarker of Neurodegeneration in Familial Frontotemporal Degeneration (f-FTD)
Rohini Khillan, PhD | Foundation for the National Institutes of Health (FNIH)
2021
$250,000
Plasma pathologic TDP-43 as a biomarker for FTLD-TDP
Qinwen Mao, MD, PhD | The University of Utah School of Medicine
2021
$500,000
Plasma neuroinflammatory biomarkers for the diagnosis of dementia subtypes
Matthew Pase | Monash University
2021
$671,160
Remote blood biomarker monitoring in frontotemporal lobar degeneration: Neurofilament Surveillance Project (NSP)
Rodney Pearlman, PhD | The Bluefield Project to Cure FTD
October 2019
$1,200,000
FTD Biomarkers Initiative
Mapping neuroinflammation in frontotemporal lobar degeneration – development of a surrogate marker for early diagnosis and disease progression
Tammaryn Lashley, MD, PhD | UCL Institute of Neurology
2019
$1,102,133.19
Accelerating tau PET imaging through head to head comparison of novel radiotracers
Tammaryn Lashley, MD, PhD | UCL Institute of Neurology
2018
$247,272
Digital Assessment Tools for FTD and ALS
Harmonizing remote smartphone assessments of cognition, behavior, and motor functioning across the spectrum of FTD and ALS
Adam Staffaroni, PhD | UCSF
2023
$350,000
Digital Measurements of Motor and Voice Functions in FTD
Ashkan Vaziri, PhD | BioSensics
2023
$399,999
Target ALS Partnership
Identification of Small Molecule Inhibitors of TDP-43 Liquid-Liquid Phase Separation
James Shorter, PhD | Merck
2016
$850,000
Treat FTD Fund
Open-label Clinical Trial of Nabilone for Neuropsychiatric Symptoms in Frontotemporal Dementia
Simon Ducharme, MD | McGill University
2021
$1,399,077.51
Evaluating the effects of GLP-1 analog, oral semaglutide, as a treatment for sporadic behavioral variant frontotemporal dementia (bvFTD)
Paul Edison, MD | Imperial College London
2021
$2,000,000
Non-Invasive Brain Stimulation for Gamma Induction and Cognitive Enhancement in FTD
Emiliano Santarnecchi, PhD | Harvard Medical School
2019
$1,959,841
Pilot Grants
PATHWAYS OF HOPE
Integrated proteomics and phosphoproteomics across FTLD-TDP subtypes
Zachary McEachin | Emory University
2023
$110,000
PATHWAYS OF HOPE
Synthetic promoter screening to uncover determinants of FTD pathology
Zevik Melamed | Hebrew University of Jerusalem
2023
$110,000
WELL-BEING IN FTD
An ethical framework for disclosure of onset-predicting biomarkers in frontotemporal dementia
Eline Bunnik, PhD | Erasmus Medical Center
2023
$93,300
WELL-BEING IN FTD
Social Network Neuromodulation in Behavioral Variant Frontotemporal Dementia
Alexandru Iordan, PhD | University of Michigan
2022
$109,784
ISFTD Infrastructure Grant
John van Swieten, PhD | International Society for Frontotemporal Dementias (ISFTD)
2023
$250,000
Clinical Research Training Scholarship in FTD
Large-scale biofluid proteomics to identify disease progression biomarkers in C9orf72 frontotemporal dementia
Rowan Saloner, PhD | UCSF
2024
$150,000
Personalized HD-tDCS in Primary Progressive Aphasia
Tanav Popli, MD | University of Michigan
2023
$150,000
Multimodal evidence of the role of Alzheimer’s disease pathology in corticobasal and progressive supranuclear palsy syndromes
Indira García Cordero, PhD | University of Toronto
2022
$150,000
Holloway Postdoctoral Fellowships
Determining the Impact of TMEM106B Fibrils on Neurons
John Replogle, PhD | National Institute of Neurological Disorders and Stroke (NIH/NINDS)
2024
$120,000
Frontotemporal Dementia (FTD) and the Criminal Legal System: An Examination of Experiences and Policies
Victoria Helmly, PhD | Georgia State University
2024
$120,000
Targeting TDP-43 aggregation as therapeutics for ALS/FTD
Marc Shenouda, PhD | University of Toronto
2023
$120,000
Virtual Reality Social Cognition Game for Preclinical Frontotemporal Dementia
Jackie Poos | Erasmus Medical Center
July 2023
$115,123
Active AFTD Awards
Translational Research
AFTD-ADDF Accelerating Drug Discovery for FTD
AFTD-ADDF Diagnostic Accelerator
Digital Assessment Tools for FTD and ALS
Holloway Fellowships
Clinical Research Training Scholarship in FTD
Holloway Postdoctoral Fellowship
English 
Spanish (Mexico) 
French 
German 
Swedish 
Portuguese 
Italian 
Dutch 
Danish 
Polish 
Spanish (Spain)